COVID-19
age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study

Since the emergency pandemic situation began, it is of high scientific significance to analyze the discriminative ability of hematologic, biochemical, inflammatory, and immunologic biomarkers in patients with and without the severe or fatal forms of COVID-19. It is necessary to determine risk categories following COVID-19 diagnosis, to ensure an optimal resource allocation and to improve clinical management and prevention of serious complications.

On admission, means of laboratory parameters, IL-6, CRP, ferritin, D-dimer, LDH, leukocyte, and neutrophil counts, were above usual reference ranges (those ranges can slightly change within centres), in contrast to lymphocyte counts and percentages as well as lymphocyte subset counts, that are within the lower part of their ranges. Higher severity was significantly associated with higher levels of IL-6, CRP, ferritin, D-dimer, LDH, leukocyte, and neutrophil counts, but with lower lymphocyte percentages and counts. The mean percentages of lymphocyte subpopulations (n = 54) were within normal ranges. CD8 Lymphocyte count was found to be significantly higher in mild cases, similar trends were found for CD4, CD19, and NK cell counts. IgG and IgM values were as well inversely related to severity.

Meridian Healthcare offers a comprehensive in vitro diagnostic solution for COVID-19 disease, aimed to support testing and surveillance, faster treatment decisions, prevention of transmission, and antimicrobial stewardship.

• IL-6 ( Interleukin-6 )
• D-Dimer
• Protein C
• G6-PDH

contact us for further information