In order to ensure correct management of the SARS-CoV-2 patient, it is necessary to characterize his G6PD status before starting the pharmacological treatment with chloroquine or hydroxychloroquine, through the medical history or by the screening or quantitative test of G6PD activity. Therefore, it is necessary to give adequate attention to the warning on the use of chloroquine and hydroxychloroquine in the presence of the enzyme G6PD deficiency.